从p-aminosalicylate功能化单体胆离子液合成的移植共聚物的表征
Aleksy Mazur1, Dorota Neugebauer1
1Department of Physical Chemistry and Technology of Polymers, Faculty of Chemistry, Silesian University of Technology, 44-100 Gliwice, Poland.
Pharmaceutics
|November 25, 2023
概括
这项研究开发了用于药物输送的新型离子液体移植共聚合物. 这些生物相容材料有效地提供抗生素p-aminosalicylate (PAS) 用于结核病治疗,具有受控释放特征.
科学领域:
- 聚合物化学 聚合物化学
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
背景情况:
- 离子液体 (ILs) 为先进材料提供独特的特性.
- ILs的生物功能化可以提高它们的生物相容性和治疗潜力.
- 开发用于结核病 (TB) 治疗的有效药物输送系统仍然是优先事项.
研究的目的:
- 合成和描述基于生物功能化的离子液体单体的新型移植共聚物.
- 为抗生素p-aminosalicylate (PAS) 创建一个受控的药物递送系统.
- 为了评估合成材料的体外药物释放性能.
主要方法:
- 通过离子交换将[2-(methacryloyloxy) ethyl]-trimethylammonium化物 (TMAMA) 与p-aminosalicylate (PAS) 的生物功能化.
- 改性单体 (TMAMA/PAS) 与甲基甲酸盐 (MMA) 的共聚合,使用"从"方法.
- 移植共聚合物组成的特征,聚合程度和侧链密度.
- 在酸盐缓冲盐水 (PBS) 介质中的体外药物释放研究.
主要成果:
- 成功合成了具有受控PAS离子含量 (高达49%) 的精确定义的移植共聚合物.
- 聚合度从12到89不等,表明可控制的侧链长度.
- 在体外释放的PAS在71-100% (2.8-9.8微克/毫升) 之间,由离子交换触发.
- 合成的材料显示出显著的药物负载和一致的释放配置文件.
结论:
- 生物功能化的离子液体移植共聚合物显示出作为有效的药物输送载体的希望.
- 控制合成允许可调节的药物加载和释放特征.
- 这些材料代表了开发新的结核病疗法的潜在进步.
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