来自同轴电的三层核心外纤维,用于改性释放甲尼达
Ying Wang1, Lin Liu2, Yuanjie Zhu2
1School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China.
Pharmaceutics
|November 25, 2023
概括
电创造了新的三层聚合物纤维,用于持续的药物输送. 这些含有甲尼达的先进纤维提供了一个有希望的新策略,用于控制肠道中药物释放.
科学领域:
- 材料科学 材料科学 材料科学
- 聚合物化学 聚合物化学
- 制药科学 制药科学
背景情况:
- 聚合物是药物输送系统的基础.
- 在过去的二十年中,电已经成为开发基于高分子的先进药物输送平台的关键技术.
研究的目的:
- 通过同轴电发展使用多种聚合物开发新的三层核心外纤维.
- 在这些纤维中封装模型药物甲基尼达 (MTD),以控制释放.
主要方法:
- 双流体同轴电聚 (乙烯基酒精) (PVA),聚 (-烯基) (PCL),尤德拉吉特RL100 (ERL100) 和尤德拉吉特S100 (ES100) 的电.
- 将甲二醇 (MTD) 加入到外乳液中.
- 使用扫描电子显微镜 (SEM),传输电子显微镜 (TEM),X射线衍射 (XRD) 和里埃变形红外光谱 (FTIR) 的表征.
- 在体外溶解测试以评估药物释放概况.
主要成果:
- 成功地制造出线性三层核心外纤维,具有独特的多腔结构.
- 在纤维中确认了MTD的无形状态及其与聚合物的兼容性.
- 在体外证明了聚合物对长期持续释放MTD的协同作用.
- 拟议的微形成机制和详细的药物控制释放机制.
结论:
- 从水和有机溶剂中创建三层核心外结构的新方法.
- 建立了先进的药物输送系统的新策略,具有复杂的,可控释放配置文件.
- 开发的纤维显示出通过持续的药物释放来增强治疗疗效的巨大潜力.
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