稳定阿斯丁纳米颗粒使用闪光纳米沉开发,以提高口服生物可用性和肝保护作用
Antara Ghosh1, Sujan Banik1, Kohei Yamada1
1Laboratory of Biopharmacy, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
Pharmaceutics
|November 25, 2023
概括
稳定阿斯塔克桑 (AX) 纳米颗粒增强了口服生物可用性和肝脏保护. 维生素E和维生素C改善了AX稳定性,显示了改善营养素特性的潜力.
科学领域:
- 营养药和食品科学 营养药和食品科学
- 纳米技术 纳米技术
- 生物化学 生物化学
背景情况:
- 阿斯塔丁 (AX) 是一种强大的抗氧化剂,其口服生物可用性和稳定性有限.
- 氧化降解和吸收不良阻碍了AX的治疗应用.
- 开发稳定和生物可利用的AX配方对于其利用至关重要.
研究的目的:
- 开发稳定性阿斯丁纳米粒子 (sNP/AX),以增强AX的物理化学特性,口服生物可用性和肝脏保护.
- 研究辅稳剂 (维生素E和维生素C) 在AX纳米粒子稳定性和性能中的作用.
- 在肝损伤的小鼠模型中评估sNP/AX的疗效.
主要方法:
- 通过使用多入口旋混合器的闪光纳米沉来准备sNP/AX.
- 维生素E (VE) 和维生素C (VC) 与波洛克萨默407一起作为联合稳定剂.
- 物理化学性质,稳定性,体内口服吸收和肝保护作用在老鼠中进行了评估.
主要成果:
- 与晶体AX相比,sNP/AX表现出更好的物理化学特性和更高的AX释放率.
- VE显著提高了储存稳定性,在4°C和25°C分别保持了94%和81%的AX在12周后.
- 在大鼠中,口服sNP/AX导致显著更高的全身AX暴露和明显减轻肝损伤.
结论:
- 稳定性阿斯丁纳米颗粒 (sNP/AX) 有效地提高了AX的口服生物可用性和肝脏保护.
- 抗氧化添加剂 (VE和VC) 的战略性纳入是提高AX稳定性和有效性的关键.
- sNP/AX代表了一种有前途的方法来提高阿斯塔克桑丁的营养药和治疗潜力.
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