结肠直肠癌:疾病过程,当前的治疗选择,以及未来的前景
Amusa S Adebayo1, Kafilat Agbaje1, Simeon K Adesina1
1College of Pharmacy, Howard University, 2400 6th St NW, Washington, DC 20059, USA.
Pharmaceutics
|November 25, 2023
概括
全球结肠直肠癌 (CRC) 发病率正在上升,这对健康构成重大挑战. 目前的治疗方法,如化疗和单克隆抗体显示出希望,但面临诸如副作用和治疗失败等局限性,需要新的方法.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 癌症研究 癌症研究
背景情况:
- 结肠直肠癌 (CRC) 是美国和全球癌症相关死亡的主要原因.
- 预计的发病率增加,特别是在发展中国家,突出了日益严重的公共卫生问题.
- 癌症的潜伏性进展和无症状性质使早期检测和诊断变得复杂.
研究的目的:
- 审查结肠直肠癌疾病的进展,当前的治疗方式,以及相关的挑战.
- 探索结直肠癌管理的未来前景和新的治疗策略.
- 综合最近关于结直肠癌瘤微环境及其在进展中的作用的发现.
主要方法:
- 使用关键词对PubMed的系统文献搜索:"结肠直肠癌"",疾病过程"",疾病机制"",当前治疗"",前景".
- 收录标准集中在2013年至2023年间发表的原创文章上.
- 严格过和详细审查选定的文章,并补充了交叉引用文献.
主要成果:
- 结肠直肠癌的发病率在各种社会经济指数上不断增加,挑战其仅仅作为一种生活方式疾病的分类.
- 右侧CRC与较差的结果有关;疾病进展通常持续7-10年.
- 目前的治疗方法包括手术,化疗 (5-甲, irinotcan,oxaliplatin,leucovorin) 和单克隆抗体 (VEGF和EGFR抑制剂),但面临着副作用和治疗耐药性等挑战.
结论:
- 尽管取得了进展,但结直肠癌治疗仍存在重大挑战,包括药物毒性和治疗失败.
- 复杂的瘤微环境是未来治疗干预的目标.
- 新的药物输送策略,如基于联体的向,正在调查中,以提高CRC治疗疗效.
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