相关实验视频
Updated: Jul 10, 2025

03:37
Self-Administration of Drugs in Mouse Models of Feeding and Obesity
Published on: June 8, 2021
4.5K
抗肥胖药物输送系统:最近的进展和挑战
Mohamed M Ashour1, Mostafa Mabrouk2, Mohamed A Aboelnasr3
1School of Biotechnology, Badr University in Cairo, Badr City, Cairo 11829, Egypt.
Pharmaceutics
|November 25, 2023
概括
新型药物输送系统 (DDS) 提供了超越传统方法的有希望,有效和特定的肥胖治疗方法. 对DDS设计的进一步研究对于开发安全有效的肥胖管理策略至关重要.
科学领域:
- 药理学和材料科学 药理学和材料科学
- 生物医学工程 生物医学工程
背景情况:
- 肥胖是一种具有重大健康和经济后果的全球流行病,预计到2030年将影响全球60%的人口.
- 传统的肥胖治疗方法,如药物治疗和减肥手术,具有局限性,包括副作用和低于最佳的疗效,需要采用替代方法.
- 使用聚合物材料和化学策略的新兴药物递送系统 (DDS) 显示出在肥胖治疗中提高治疗效率和特异性的潜力.
研究的目的:
- 提供当前和传统的抗肥胖治疗策略的全面审查.
- 讨论用于肥胖管理的药物输送系统 (DDS) 的设计和创建.
- 解决有关影响DDS有效性的复杂物理和化学参数的知识差距,包括基于微针的系统.
主要方法:
- 对现有的抗肥胖疗法和新兴药物输送系统的文献综述.
- 分析肥胖症治疗的DDS设计中的物理和化学参数之间的相互作用.
- 探索先进的DDS技术及其在临床前 (动物研究) 和未来临床应用中的潜力.
主要成果:
- 目前的文献缺乏深入的审查,重点是专门用于治疗肥胖症的DDS的开发和设计.
- 包括微针在内的DDS的有效性取决于合成方法和物理/化学性质的复杂相互作用.
- 先进的DDS技术在开发更安全,更有效的肥胖治疗方面具有显著的前景.
结论:
- 迫切需要新的,有效的和特定的肥胖治疗方法.
- 药物输送系统 (DDS) 是推动肥胖治疗的关键研究领域.
- 进一步研究DDS的设计和合成对于实现其在控制肥胖方面的全部潜力至关重要.
相关概念视频
Drug Delivery: Overview
296
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
296
Drug Delivery: Miscellaneous Routes
357
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
357
Drug Delivery: Parenteral Route
557
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
557
Drug Delivery: Enteral Route
463
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
463
Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport
551
Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
551
Biopharmaceutics and Pharmacokinetics: Overview
2.0K
Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
2.0K

