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基于多的系统:从合成到药物输送中的应用
Mariia Stepanova1, Alexey Nikiforov1, Tatiana Tennikova2
1Institute of Macromolecular Compounds, Russian Academy of Sciences, Bolshoy pr. 31, 199004 St. Petersburg, Russia.
Pharmaceutics
|November 25, 2023
概括
合成聚胺提供了多功能药物输送解决方案. 本综述涵盖了它们的合成,纳米粒子/水凝应用,以及先进疗法的关键性质.
科学领域:
- 聚合物化学 聚合物化学
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
背景情况:
- 合成聚类是生物相容和生物降解的大分子.
- 它们的组成,结构和氨基酸多样性允许调节的物理化学和生物特性.
- 多可以形成二次结构,并被修改为生物功能.
研究的目的:
- 审查合成聚和共聚合物合成方面的进展.
- 总结聚系统在药物输送中的应用,重点是纳米粒子和水凝.
- 讨论影响聚基药物递送系统性能的关键因素.
主要方法:
- 综合聚合成和应用的综合文献综述.
- 对各种聚类纳米粒子类型,制备方法和药物加载策略的分析.
- 评估影响稳定性,可降解性,细胞相互作用和免疫性的物理化学特征.
主要成果:
- 基于多的纳米颗粒和水凝显示出对各种药物输送应用的前景.
- 物理化学性质显著影响纳米粒子稳定性,细胞吸收,细胞毒性和免疫性.
- 有成功的纳米配方存在于,蛋白质,基因传递,癌症治疗和抗菌/抗炎系统.
结论:
- 合成聚酸具有很高的适应性,可用于创建先进的药物输送载体.
- 了解结构-性质关系对于优化聚基纳米药物至关重要.
- 对聚合成和纳米配方的进一步研究将推动针对性疗法的创新.
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