血清学证据显示,巴西马匹感染了E型肝炎病毒
Caroline Roberta Soares Salgado1, Aldaleia do Nascimento E Silva1, Igor Falco Arruda2
1Laboratório de Desenvolvimento Tecnológico em Virologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz-Fiocruz, Rio de Janeiro 21040-900, RJ, Brazil.
Microorganisms
|November 25, 2023
概括
巴西马的肝炎E病毒 (HEV) 暴露已被证实,超过26%的马体显示出抗体. 供食用肉类的马类有更高的风险,这凸显了对马群中HEV监测的必要性.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 肝炎E病毒 (HEV) 在各种动物物种中循环,其中一些动物物种充当动物性传染病储存库.
- 3型HEV基因型在巴西人类和猪中普遍存在,并且已在子,牛和鱼中检测到.
- 关于巴西马群中HEV暴露的数据有限.
研究的目的:
- 为了确定抗HEV抗体的血清流行率,并检测巴西马的HEVRNA.
- 为了确定与马类的HEV暴露相关的潜在风险因素.
- 评估马在HEV流行病学中的作用. 在一个健康框架内.
主要方法:
- 来自257匹马的血清样本使用修改后的ELISA套件对抗HEVIgG进行了分析.
- 使用嵌套RT-PCR和RT-qPCR检测到了HEVRNA.
- 进行了统计分析,以确定风险因素,如性别和繁殖系统.
主要成果:
- 观察到总体HEV血清流行率为26.5%,没有检测到HEVRNA.
- 为了人类食用而屠宰的马与运动/繁殖马 (6.4%) 相比,暴露于HEV (45.5%) 的水平显著更高.
- 在市镇和农场中,HEV暴露很普遍,性别和繁殖系统被确定为潜在的风险因素.
结论:
- 这项研究提供了第一个关于巴西马匹中HEV循环的血清学证据.
- 这些发现强调了将马纳纳入HEV监测计划的重要性.
- 一个健康的方法对于理解和管理HEV宿主扩张至关重要.
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