肺炎球菌血清类型与西班牙成年人社区获得的肺炎住院相关,2016-2020年:CAPA研究
Rosario Menéndez1,2, Antoni Torres2,3, Pedro Pablo España4
1Hospital Universitario y Politécnico la Fe, 46026 Valencia, Spain.
Microorganisms
|November 25, 2023
概括
高价值的肺炎球菌联合疫苗 (PCV) 可以减少成人社区获得性肺炎 (CAP). 在西班牙,PCV20血清型导致了大多数肺炎球菌CAP病例,突出了疫苗减少疾病负担的潜力.
科学领域:
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 社区获得性肺炎 (CAP) 仍然是成年人的重大公共卫生问题.
- 更高价值的肺炎球菌联合疫苗 (PCVs) 在减轻CAP的负担方面表现有前途.
- 了解导致CAP的*Streptococcus pneumoniae*的血清型分布对于疫苗开发和公共卫生战略至关重要.
研究的目的:
- 描述西班牙成人CAP血清型的演变和分布.
- 专注于包括在20肺炎球菌联合疫苗 (PCV20) 中的血清型.
- 评估PCV20对减少成人CAP的潜在影响.
主要方法:
- 胸部X射线的前性观察性研究证实了在西班牙四家医院 (2016年11月 - 2020年11月) 的住院,免疫能力强的成年人中的CAP.
- 通过血液培养和尿路抗原检测,使用BinaxNow®,UAD1和UAD2测试来识别肺炎球菌.
- 分析血清型的流行情况,特别是那些被PCV20所覆盖的血清型.
主要成果:
- 在1948年住院的CAP患者中, *Streptococcus pneumoniae* 在34.9%的患者中被发现.
- 疫苗类型PCV20血清型占所有CAP病例的23.9%和肺炎球菌CAP的68.4%.
- 血清型8和3是最常见的整体,与PCV20相关的血清型导致大部分的肺炎球菌CAP.
结论:
- 肺炎菌是西班牙成年人住院CAP的常见原因之一.
- 肺炎球菌CAP的很大一部分是由PCV20.20向的血清型引起的.
- 高价值的PCV,如PCV20,具有相当大的潜力,可以减少西班牙成年人CAP的负担.
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