在接种COVID-19疫苗的结核病感染患者中,T细胞反应
Luiz Henrique Agra Cavalcante-Silva1, Ericka Garcia Leite1, Fernanda Silva Almeida1
1Immunology of Infectious Diseases Laboratory, Department of Cellular and Molecular Biology, Federal University of Paraiba, João Pessoa 58051-900, PB, Brazil.
接种COVID-19疫苗会影响结核病患者的T细胞反应. 与未接种疫苗的患者相比,接种疫苗的个体显示出CD4+和CD8+T细胞细胞因子的变化,这表明对同时感染控制的潜在影响.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
背景情况:
- 与SARS-CoV-2 (导致COVID-19的病毒) 和Mycobacterium结核病 (Mtb) 的同时感染带来了复杂的健康挑战.
- 虽然COVID-19疫苗接种可以控制严重的疾病,但轻度或无症状的感染仍然可能与结核病 (TB) 一起发生.
研究的目的:
- 为了比较COVID-19未接种疫苗的T细胞对SARS-CoV-2抗原的免疫反应与活跃结核病的接种疫苗的患者.
- 调查COVID-19疫苗接种对T细胞激活和细胞因子产生的影响,在与Mtb.同时感染的人群中.
主要方法:
- 利用流细胞计分析CD4+和CD8+T细胞反应.
- 在用SARS-CoV-2刺激后评估T细胞激活标记物 (CD69,CD137) 和细胞因子 (IFN-γ,TNF-α,IL-17,IL-10).
- 接种疫苗和未接种疫苗的结核病患者之间的比较反应.
主要成果:
- 与接种疫苗的结核病患者相比,未接种疫苗的结核病患者表现出较高的CD69和TNF-α后病毒挑战的CD8+T细胞频率.
- 接种疫苗的结核病患者在尖峰刺激后产生IL-10的CD4+T细胞的频率高于未接种疫苗的患者.
- 在其他分析的T细胞激活标志物或细胞因子中没有发现显著差异.
结论:
- 在活跃的结核病患者中,COVID-19疫苗似乎调节了T细胞反应.
- 观察到T细胞形状的变化,特别是接种疫苗的患者IL-10的增加,可能表明免疫平衡发生了变化.
- 需要进一步的研究,以了解这些免疫变化的临床影响,以控制同时感染和疫苗接种后的结果.
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