提高可塑化聚乙烯化物的疏水性,以便在内管中使用
Lavinia Marcut1,2, Aurel George Mohan1,3, Iuliana Corneschi4
1Faculty of Medicine and Pharmacy, University of Oradea, 10 P-ta 1 December Street, RO-410073 Oradea, Romania.
Materials (Basel, Switzerland)
|November 25, 2023
概括
研究人员通过增加其疏水性质来增强内管 (ETT). 这种使用等离子处理和PTFE目标的表面修饰旨在减少微生物的附着和生物膜的形成,提高患者的安全性和降低医院成本.
科学领域:
- 生物材料工程 生物材料工程
- 聚合物科学 聚合物科学
- 医疗器械开发 医疗器械开发
背景情况:
- 由塑化聚乙烯 (PVC) 制成的内管 (ETT) 容易受到微生物的附着和生物膜的形成.
- 这可能导致与设备相关的感染,增加患者的痛苦和医疗保健成本,这是COVID-19大流行期间加剧的担忧.
- 塑化剂从PVC中的迁移也支持微生物的生长.
研究的目的:
- 提高商业ETT的表面性能,以减少微生物粘附.
- 在ETT上开发出更水的表面,以防止生物膜形成和相关的感染.
- 为了提高ETT材料的生物相容性.
主要方法:
- 通过使用SF6放电和磁铁喷射与PTFE目标的等离子处理对PVC ETT样本的表面修饰.
- 使用XPS,ATR-FTIR,CA,SEM+EDAX,形状测量,密度,Shore A硬度和TGA-DSC进行修改表面的表征.
- 对修改ETT样品的抗菌和生物相容性质的评估.
主要成果:
- 成功地提高了塑性PVCETT表面的疏水特性.
- 经过修改的ETT样品的生物相容性性能有所改善.
- 表面修饰有效地改变了材料与生物环境的相互作用.
结论:
- 通过等离子处理和PTFE喷进行表面化是一种有效的方法来增强ETT的疏水性.
- 开发的疏水型ETT表面显示出有希望的生物相容性和减少设备相关感染的潜力.
- 这种方法提供了一种可行的策略,以提高内管的安全性和有效性.
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