优化功能牙膏配方含有纳米-氧和树提取物用于日常口腔护理
Alexandra-Diana Florea1, Cristina Teodora Dobrota1,2, Rahela Carpa2
1Research Center of Physical Chemistry, Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University, 11 Arany Janos Str., 400028 Cluj-Napoca, Romania.
Materials (Basel, Switzerland)
|November 25, 2023
概括
新的牙膏含有纳米-酸 (nHAPs) 和树提取物有效地重矿化牙,并抑制细菌. 配方P5在10天内显示出增强口腔护理和牙修复的有希望的结果.
科学领域:
- 生物材料科学 生物材料科学
- 在口腔健康中纳米技术
- 微生物学与牙损
背景情况:
- 牙损仍然是一个重要的全球健康问题,需要新的治疗策略.
- 纳米酸酸盐 (nHAPs) 显示出对质重矿化的承诺,而天然提取物则提供抗菌潜力.
- 将这些药物结合在牙膏中可以提供一种双重作用的口腔护理方法.
研究的目的:
- 开发和评估功能性牙膏,其结合了牙质的重矿化和抗菌特性.
- 为了研究不同的nHAP配方和树提取物度的疗效.
- 评估对去矿物质化的面膜的修复作用和对关键口腔病原体的抗菌活性.
主要方法:
- 11种牙膏配方 (P1-P11) 使用纯或替代的nHAP和不同度的树提取物.
- 在体外重矿化被评估在使用原子力显微镜 (AFM) 的去矿化面膜片.
- 通过阿加盘扩散方法对*Enterococcus faecalis*,*E. coli*,*P. gingivalis*,*S. mutans*和*S. aureus*进行抗菌活性评估.
主要成果:
- 牙膏治疗显示出出色的牙面膜修复性质,在10天内使纳米结构正常化并减少表面粗度.
- 对所有测试的口腔病原体观察到显著的抗菌作用.
- 配方P5,含有HAP-5%Zn (3.4%) 和树提取物 (1.3%),表现出特别强大的再生矿物和抗菌功效.
结论:
- 开发的牙膏有效地促进了牙面膜的重矿化,并表现出广泛的抗菌活性.
- 结合nHAP和树提取物,为先进的口腔护理产品提供了一个有前途的战略.
- 配方P5代表了牙膏中同时修复牙质和抑制细菌的潜在突破.
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