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Updated: Jul 10, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
05:33

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

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基于IGF2的LYTACs用于对细胞外和膜外蛋白的有针对性的降解

Michał Mikitiuk1,2, Jan Barczyński1,2, Przemysław Bielski1

  • 1Recepton Sp. z o.o., Trzy Lipy 3, 80-172 Gdańsk, Poland.

Molecules (Basel, Switzerland)
|November 25, 2023
PubMed
概括

纯蛋白质色素向仿真体 (LYTACs) 为向降解提供了一个可扩展的替代方案. 这些新型LYTACs有效降解编程死亡联体1 (PD-L1),显示出对传统抗体的增强疗效.

关键词:
在LYTAC中,我们可以使用LYTAC在PD-1中使用PD-1.在PD-L1中.免疫检查点封锁 封锁有针对性的蛋白质降解降解.

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