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在体外抗瘤和低血糖的作用,来自柳叶芽的总黄类

Peng Zhang¹, Lulu Fan¹, Dongyan Zhang¹

¹College of Life Engineering, Shenyang Institute of Technology, Fushun 113122, China.

Molecules (Basel, Switzerland)

|November 25, 2023

概括

柳叶芽 (PTFW) 的总黄素对宫癌,结肠癌和乳腺癌细胞具有显著的抗癌作用. 此外,PTFW还通过抑制关键酶,表现出显著的低血糖活性,这表明其有可能用于制药和食品应用.

科学领域:

植物化学植物化学
药理学药理学是指药理学的学科.
癌症研究癌症研究

背景情况:

柳树 (Salix babylonica L.) 是一种装饰性植物,其药用潜力不发达.
柳叶芽含有黄类化合物,其治疗性质在很大程度上尚未开发.

研究的目的:

提取和分析柳芽 (PTFW) 的全部黄类化合物.
评估PTFW的体外抗瘤和低血糖活性.

主要方法:

使用Q-Orbitrap LC-MS/MS进行成分分析,确定了10种类黄化合物.
在HeLa,HT-29和MCF7癌细胞系上通过MTT试验评估的体外抗瘤活性.
低血糖活性通过测量α-氨酶和α-葡萄糖酶的抑制来评估.

主要成果:

PTFW显著抑制了HeLa (IC50=1.432毫克/毫升),HT-29 (IC50=0.3476毫克/毫升) 和MCF7 (IC50=2.297毫克/毫升) 细胞的增殖.
PTFW证明了对α-氨基酶 (IC50=2.94 mg/mL) 和α-葡萄糖酶 (IC50=1.87 mg/mL) 的抑制作用.

结论:

PTFW在经过测试的癌细胞系,特别是HT-29.9上表现出剂量依赖的抗增殖效应.
PTFW具有显著的低血糖特性,表明功能性食品和药品的潜力.

关键词:

Q-轨道飞行器LC-MS/MS/Q-轨道飞行器这是一种抗瘤药物.低血糖症是一种低血糖症.总的黄类化合物总量柳树的芽柳树的芽

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