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银河酸调解NF-κB通路,改善肠道屏障功能和肠道微生物群
1College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China.
Molecules (Basel, Switzerland)
|November 25, 2023
概括
在婴儿配方中补充银醇糖 (GOS) 可以帮助在抗生素治疗后恢复肠道微生物群的多样性. GOS促进有益的细菌,增强肠道屏障功能,减少炎症,防止肠道损伤.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 早期使用抗生素可以破坏婴儿肠道微生物群,导致与免疫相关的疾病.
- 寡糖类,就像银寡糖类 (GOS),对于构建和维护肠道微生物群多样性至关重要.
- 关于GOS对肠道微生物群多样性,疾病和肠道屏障功能的影响的研究有限.
研究的目的:
- 在接受抗生素治疗的小鼠模型中研究GOS对肠道微生物群和屏障功能的影响.
- 评估GOS在减轻抗生素诱导的肠损伤和相关的免疫失调方面的潜力.
主要方法:
- 16S rRNA测序以分析肠道微生物群的组成.
- 气相色谱用于测量短链脂肪酸水平.
- 免疫组织化学评估紧结蛋白表达和炎症标志物.
主要成果:
- 补充GOS促进了有益细菌的繁殖,包括Bifidobacterium和Akkermansia.
- GOS增加了短链脂肪酸,紧结蛋白 (occludin,ZO-1),分泌IgA和专蛋白水平.
- GOS显著降低了NF-κB的调节,减少了LPS,IL-1β和IL-6,并防止肠道损伤,特别是在高剂量时.
结论:
- 在接受抗生素治疗的小鼠中,GOS有效调节肠道微生物群,并增强肠道屏障功能.
- GOS显示出作为一种益生菌补充剂的潜力,可以预防或治疗婴儿肠道疾病和与免疫相关的疾病.
- 进一步研究GOS作为婴儿营养中的功能成分是有必要的.
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