关于自然植物分子调节阿尔茨海默病中血脑屏障的研究进展
Weidong Wu1, Jiahao Huang2, Pengfei Han3
1Basic Theory of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Molecules (Basel, Switzerland)
|November 25, 2023
概括
自然植物分子通过影响血脑屏障 (BBB) 显示出对阿尔茨海默病 (AD) 治疗的希望. 本综述探讨了他们开发更安全,更有针对性的AD疗法的机制.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
背景情况:
- 阿尔茨海默病 (AD) 是一个日益严重的全球健康问题,给人类带来了巨大的负担.
- 目前的阿尔茨海默病治疗疗法有效性有限,并具有不良影响.
- 阿尔茨海默病的复杂病理阻碍了有效的药物开发.
研究的目的:
- 为了审查自然植物分子影响血脑屏障 (BBB) 的AD治疗.
- 分析这些天然化合物的机制.
- 为开发新型AD疗法提供见解.
主要方法:
- 在体内和体外研究的全面审查.
- 在AD模型中分析针对BBB的天然植物分子.
- 检查分子作用机制的作用.
主要成果:
- 自然植物分子在调节AD病理学方面表现出潜力.
- 一些化合物通过影响BBB表现出有益作用.
- 多种向途径比传统药物具有优势.
结论:
- 自然植物分子为AD药物开发提供了一个有前途的途径.
- 用天然化合物准BBB可能会导致更安全,更有效的治疗方法.
- 需要进一步的研究,以便在AD预防和治疗中获得临床应用.
相关概念视频
00:49The Blood-brain Barrier
47.4K
Overview
47.4K
01:22Alzheimer's Disease: Treatment
195
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
195
01:26Alzheimer's Disease: Overview
494
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
494