在"块"迷你质谱仪上复杂化四极体和离子陷操作模式
Chaohong Feng1, Siyu Liu1, Ting Jiang1
1School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China.
Molecules (Basel, Switzerland)
|November 25, 2023
概括
一个新的微型质谱仪集成了四极和离子陷质量分析仪,扩大了分析能力. 这种综合系统可以提高各种分析挑战的性能.
科学领域:
- 分析化学 分析化学
- 质谱仪器仪器仪表仪器仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表仪表
背景情况:
- 四极和离子陷质量分析仪提供互补的功能,但通常需要单独的仪器.
- 将多样化的分析能力集成到一个单一的,紧的系统中,是质谱发展的关键目标.
研究的目的:
- 开发一种单一的质量分析仪,能够在四极和离子陷模式下运行.
- 提高微型质谱仪的分析覆盖范围和多功能性.
主要方法:
- 一个基于印刷电路板 (PCB) 的多电极四极极离子陷质量分析仪被设计和集成.
- 两个电离源,纳米电子喷雾电离和真空等离子体电离,用于广泛的分子分析.
- 仪器的性能以四极和离子陷模式为特征,评估质量范围,分辨率和灵敏度.
主要成果:
- 四极模式成功分析了从31到502 Th. 的离子.
- 离子陷模式覆盖了高达922 Th的较高质量电荷比,并使联质谱学成为可能.
- 集成系统展示了四极管和离子陷模式的多重操作.
结论:
- 开发的微型质谱仪成功地将四极和离子陷功能在单个质量分析仪中结合起来.
- 这种整合显著扩大了各种化学分析的分析能力和解决问题的潜力.
- 基于PCB的设计和双电离源为多功能和高性能分析仪器做出了贡献.
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