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Updated: Jul 10, 2025

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
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Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates

Published on: February 27, 2016

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作为SIRT2抑制剂的5-(((3-阿米多基) 氧) 尼古丁胺胺:对受限制类型的研究

Teng Ai1, Daniel J Wilson1, Liqiang Chen1

  • 1Center for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.

Molecules (Basel, Switzerland)
|November 25, 2023
PubMed
概括

研究人员开发了基于尼古丁胺胺支架的新型SIRT2抑制剂. 约束性 (S) 异构体表现出增强的活性和选择性,为癌症和神经退行等疾病提供了潜在的治疗应用.

关键词:
一个SIRT1系统.在SIRT2中,SIRT2是SIRT2.在SIRT3中,SIRT3是最重要的.有限制的抑制剂抑制剂.锡尔图因抑制剂的使用这里是Sirtuinsins的所在地.

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