dsRNA菌的多样性和当前分类
Sari Mäntynen1, Meri M Salomaa1, Minna M Poranen1
1Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, 00014 Helsinki, Finland.
Viruses
|November 25, 2023
概括
发现 Pseudomonas 菌体 phi6 揭示了第一个包裹式 dsRNA 菌体. 随后的研究表明,这些病毒广泛传播,以不同的策略感染了Pseudomonas菌株.
科学领域:
- 病毒学 病毒学
- 微生物学 微生物学
- 基因组学就是基因组学.
背景情况:
- 发现Pseudomonas菌体phi6标志着第一个包裹式双链RNA (dsRNA) 菌的鉴定.
- 25年来,phi6是唯一已知的dsRNA菌体,也是Cystoviridae家族的唯一成员,直到2018年.
研究的目的:
- 审查Cystoviridae家族的公认成员和相关的dsRNA菌体分离物.
- 概述 dsRNA 菌体的当前分类.
- 讨论dsRNA菌体和真核RNA病毒之间的进化关系.
主要方法:
- 关于dsrna菌体的已发表研究的文献综述.
- 对 dsRNA 菌体分离物的可用完整基因组序列的分析.
- 比较基因组学以确定共享的基因组和进化轨迹.
主要成果:
- 在全球和元转录组数据中发现了额外的dsRNA菌体,这表明患病率更大.
- 大多数dsRNA菌体感染了Pseudomonas菌株,使用 pili 或 lipopolysaccharides 作为受体.
- 有14个完整的dsRNA菌体基因组,显示了序列多样性,但保留了基因组.
结论:
- dsRNA菌体,特别是Cystoviridae家族中的菌体,比以前认为的更普遍.
- 这些病毒表现出多样化的感染策略,包括溶性和持久的生活方式.
- 共享的遗传元素表明dsRNA菌体的共同进化路径,与真核RNA病毒的潜在联系.
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