雄性的基因组中的内源性病毒元素
Miranda Barnes1, Dana C Price1
1Center for Vector Biology, Department of Entomology, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA.
Viruses
|November 25, 2023
概括
中的内源性病毒元素 (EVE) 揭示了多样化的病毒起源和共同的祖先,为宿主病毒相互作用和潜在的病原体监测提供了洞察力. 这些病毒化石有助于理解传播疾病的动态.
科学领域:
- 基因组学就是基因组学.
- 病毒学 病毒学
- 节肢动物生物学
背景情况:
- 内源性病毒元素 (EVE) 是病毒衍生的遗传物质,集成到宿主基因组中.
- EVE及其衍生小RNA在RNA干扰 (RNAi) 途径中发挥作用,影响宿主对病毒感染的防御.
- 了解关节动物中的EVE,特别是虫等疾病载体,对于理解宿主-病原体相互作用和载体能力至关重要.
研究的目的:
- 通过生物信息学方法在九种硬物种中识别和表征内源性病毒元素 (EVE).
- 为了研究导致虫中EVE的病毒类型的多样性.
- 探索已识别的EVE的进化关系和共同祖先.
主要方法:
- 对9个可用的硬基因组序列的生物信息分析.
- 内源性病毒元素 (EVE) 的识别和分类.
- 进行比较分析以确定EVE的病毒多样性和共同祖先.
主要成果:
- 在分析的基因组中识别了1234个EVE,这些EVE来自各种各样的病毒种群.
- 在Ixodes物种中有大量的Mononegavirales (Rhabdoviridae) 和广泛的Adintovirus集成.
- 虫中Bunyavirales EVEs的流行,其中一些元素类似于已知的人类和兽医病原体.
结论:
- 基因组拥有丰富的病毒整合历史,反映了各种祖先的病毒暴露.
- 已识别的EVE提供了对过去病毒感染和病毒防御的潜在机制的见解.
- 这些发现是用于tick-omics数据质量控制和理解传播病原体演变的宝贵参考.
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