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设计一种基于标签/捕获器生物结合的新型模块化腺病毒mRNA交付平台

Kexin Geng1,2, Paul J Rice-Boucher1,2, Elena A Kashentseva1

  • 1Department of Radiation Oncology, Biologic Therapeutics Center, Washington University School of Medicine, St. Louis, MO 63110, USA.

Viruses
|November 25, 2023
PubMed
概括

这项研究引入了一种新的腺病毒mRNA输送平台,增强了疫苗技术. 新系统有效地提供mRNA,并显示了改善T细胞反应的潜力,克服了当前的局限性.

关键词:
捕获者/标签生物结合生物结合这是一种RNA结合蛋白.腺病毒的病毒.这就是mRNA凝结的过程.提供mRNA的交付.疫苗 疫苗 疫苗 疫苗

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Tagging and Fusion Proteins01:24

Tagging and Fusion Proteins

Proteins are involved in several cellular processes and biochemical reactions. Analyzing a specific protein of interest requires it to be isolated from the other proteins in the cell. This is achieved by overexpressing the specific gene in a suitable host to produce large quantities of the target protein. A tag or label is recombined with the gene to produce a fusion protein containing the target protein and the tag. The tags on these fusion proteins can then be used for easy detection and...