癌症患者的COVID-19抗体血清转化:治疗停止的影响 - 一个单中心研究
Lina Souan1, Hikmat Abdel-Razeq2,3, Sura Nashwan1
1Department of Pathology & Laboratory Medicine, King Hussein Cancer Center, Amman 11941, Jordan.
Vaccines
|November 25, 2023
概括
像BNT162b2 mRNA和BBIBP-CorV这样的COVID-19疫苗在接受治疗的癌症患者中诱导幽默性免疫反应. 癌症患者在接种疫苗后的血清转化率有所改善,BNT162b2的初始疗效更高.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 疫苗学 疫苗学 疫苗学
背景情况:
- 接种COVID-19疫苗对于减轻大流行病危害至关重要.
- 在接受活性治疗的癌症患者中研究了BNT162b2 mRNA和BBIBP-CorV疫苗的免疫性.
- 专注于疫苗接种后的血清转化率和抗体标位.
研究的目的:
- 评估两种COVID-19疫苗在接受积极治疗的癌症患者中的疗效.
- 评估幽默免疫反应,特别是血清转化率和抗体水平.
- 在这个人群中比较BNT162b2 mRNA和BBIBP-CorV疫苗的性能.
主要方法:
- 134名正在接受积极治疗的癌症患者接种了SARS-CoV-2疫苗.
- 在接种疫苗后收集了三个血液样本 (T0,T1,T2).
- 使用ABBOTT-SARS-CoV-2 IgG II Quant和Elecsys® Anti-SARS-CoV-2试验量化抗体标位,报告在世卫组织 (BAU) /mL.
主要成果:
- 癌症患者在T2时表现出增加的血清转化率,无论疫苗类型如何.
- 与T0.0相比,T1和T2的平均抗体标位在T1和T2显著更高.
- BNT162b2在T0-T1之间显示出更高的血清转化率,这表明BBIBP-CorV接受者可能需要增强剂.
- 比较阿博特和罗氏测定结果需要考虑样本采集时间.
结论:
- COVID-19疫苗可以在接受活性治疗的癌症患者中引起幽默性免疫反应.
- 长期监测抗体水平使用两个免疫测试在这个队列是一个关键的优势.
- 需要进一步的多中心研究,使用更大的患者队列来证实这些发现.
关键词:
BBIBP-CorV病毒病毒在 COVID-19 疫情中,的IgG抗体标位.瑞生物科技公司 (BNT162b2)这就是SARS-CoV-2病毒.积极的癌症治疗疗法.癌症患者 癌症患者不活化的疫苗.这是mRNA疫苗.更多相关视频
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