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内免疫疗法的免疫治疗剂

Chih-Rong Shyr^1,2, Lang-Chi Liu³, Hui-Shan Chien¹

¹Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404328, Taiwan.

|November 25, 2023

概括

与全身疗法相比,内免疫疗法提高了癌症治疗的疗效,并减少了副作用. 将内和全身策略与精准医学相结合,为癌症治疗提供了一个有前途的未来.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
癌症治疗方法癌症治疗方法

背景情况:

系统性免疫疗法,如免疫检查点抑制剂 (ICI) 和仿真抗原受体 (CAR) T 细胞,提供了革命性的癌症治疗方法,但对患者的好处有限.
系统性治疗可以导致严重的自身免疫毒性和细胞因子风暴,而免疫抑制性瘤微环境 (TME) 则导致治疗无效.
与免疫相关的不良事件 (irAEs) 是当前全身免疫疗法的一个重大问题.

研究的目的:

审查和讨论内免疫疗法药物及其机制.
探索内免疫疗法的潜力,以提高疗效和减少全身毒性.
概述临床实践中内免疫疗法的挑战和未来方向.

主要方法:

对内免疫治疗剂的临床前模型和临床试验的审查.
分析这些药物如何刺激免疫系统以触发抗瘤免疫.
讨论涉及系统和内治疗的组合策略.

主要成果:

免疫刺激剂的内注射表明对注射和非注射的病变具有抗瘤作用.
免疫治疗剂在瘤内的生物可用性增加可以提高治疗效率.
内治疗方法显示出降低免疫治疗相关的全身毒性潜力.

结论:

内免疫疗法是一个有希望的策略,可以克服系统治疗的局限性.
结合内和全身免疫疗法,最大限度地提高了身体对抗癌症的免疫反应.
将精准医学与免疫治疗结合在一起,提供了一种同时的方法来准瘤突变并加强免疫系统.

关键词:

抗瘤免疫力免疫力身体身体身体身体身体身体身体身体免疫治疗免疫治疗免疫治疗在口内入口.新抗原是一种新抗原.作为一个异种抗原,它具有异种抗原.

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