在患有喉状细胞癌的人的癌症组织中调节3C和4D表达的semaphorin
Marzieh Sajadian1, Bijan Khademi2,3, Leila Moinzadeh4,5
1Department of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
The Indian journal of medical research
|November 25, 2023
概括
赛马福林3C (Sema3C) 基因表达增加,而赛马福林4D (Sema4D) 在喉状细胞癌 (LSCC) 组织中减少. 这些发现表明Sema3C和Sema4D可能是LSCC瘤生长的关键调解者.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 赛马福林是最初被确定为轴突引导的蛋白质.
- 它们在生理过程中扮演着不同的角色,包括免疫反应,血管新生和器官发育.
- 赛马福林可以通过各种机制影响瘤的进展.
研究的目的:
- 为了研究semaphorin (Sema) 基因转录和血管内皮生长因子 (VEGF) 的表达.
- 评估喉状细胞癌 (LSCC) 患者的Sema3A血清水平.
主要方法:
- 使用定量实时PCR来确定30名患者LSCC和相邻组织中的Sema3A,Sema3C,Sema4D,Sema6D和VEGF的组织表达.
- 酶相关免疫吸收试验 (ELISA) 用于测量血清Sema3A水平.
主要成果:
- 与非瘤组织相比,瘤组织中的Sema3C基因转录水平显著升高 (P=0.001).
- 在瘤组织中,Sema4D基因转录水平显著下降 (P≤0.01).
- 塞马3C表达与晚期瘤阶段相关 (第四阶段,P<0.01).
- 在LSCC患者和对照人群之间没有观察到血清Sema3A水平的显著差异.
结论:
- 在LSCC瘤组织中Sema3C的增加和Sema4D的减少表明它们作为瘤生长中的关键调解者的潜在作用.
- 这些发现可能为LSCC治疗提供新的治疗策略.
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