在ex vivo人体心室中复杂的再极化动态是独立于归还性质的
Shahriar Iravanian1, Ilija Uzelac2, Anand D Shah1
1Department of Medicine, Division of Cardiology, Emory University School of Medicine, 1364 Clifton Road, Atlanta, GA 30322, USA.
概括
在人类心脏中发现了复杂的再极化动态,被确定为更高阶周期性. 这些不稳定的区域可以指导切除策略,以防止心室动 (VF).
科学领域:
- 心血管电生理学 心血管电生理学
- 心律失常的机制 心律失常的机制
- 计算生物学 计算生物学
背景情况:
- 心室动 (VF) 的机制尚不清楚,这限制了有效的切除策略.
- 目前的模型,如复极化交替子,不能完全解释VF启动.
- 存在识别和准心脏中电气不稳定的基质的需要.
研究的目的:
- 为了研究复杂的再极化动力学,超越了人类心脏中的经典替代.
- 为了确定更高阶周期是否是电动不稳定性的标记.
- 评估针对这些地区进行VF消去的潜力.
主要方法:
- 在快速节奏过程中,对被扩张的人类心脏进行光学映射.
- 从右心室分析内心脏再极化动态.
- 使用像素分析检测全球和本地再极化周期性.
主要成果:
- 在人类心脏中观察到更高阶的周期性 (周期4,6,8).
- 这些复杂动态的空间异质分布是显而易见的.
- 恢复属性和检测到的周期性之间没有发现显著的相关性.
结论:
- 复杂的高阶周期性与人类心脏中的稳定区域共存的证据.
- 循环机械中的振荡被推断为更高阶动态的机制.
- 这些地区代表了基底基结除的潜在目标,以减少VF风险.
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