在骨底部病理的内镜内性垂体转移后术后低血的发生率
Francesca Galbiati1, Sharini Venugopal2, Hussam Abou-Al-Shaar3
1Department of General Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Pituitary
|November 25, 2023
概括
对瘤进行的垂体移植手术可以导致超过一半的患者出现低血症. 较窄的外科角度和较小的瘤扩展增加了这种风险,有助于患者风险分层.
科学领域:
- 神经外科 神经外科
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
背景情况:
- 垂体转移是一种新兴的手术技术,用于进入体内体空间和体间.
- 有限的数据存在于手术后的结果,特别是低血的发病率,在下垂体转移后.
研究的目的:
- 为了评估手术后低血症的发生率,在下垂体转移后.
- 为了确定与此过程后低血症相关的解剖学和手术因素.
主要方法:
- 追溯分析72名接受内内性垂体转移治疗的非垂体瘤患者.
- 收集了关于前垂体缺陷,激素替代,瘤病理和手术前水平的数据.
- 通过统计测试和后勤回归,评估手术后的水平并分析解剖学参数 (细胞高度,接入角度,瘤延伸比率).
主要成果:
- 超过一半 (55.6%) 的患者患有术后过渡性低血症.
- 严重的低血量 (<120 mmol/L) 在5%的患者中发生.
- 低血症与细胞接入角 (p=0.02) 有相反的关联,与瘤骨延伸 (p=0.09) 有意义的趋势.
结论:
- 过渡性低血是脑下垂体转移后的一个常见并发症.
- 较窄的细胞进入角度和较小的瘤扩展在细胞底上方与增加的低血症风险有关.
- 解剖学和手术参数可以帮助分层患有术后低血风险的患者.
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