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在临床前研究中,针对免疫检查点PET的放射性标记抗体

Milou Boswinkel¹, Gerben M Franssen¹, Sandra Heskamp²

¹Department of Medical Imaging, Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

Methods in molecular biology (Clifton, N.J.)

|November 25, 2023

概括

免疫检查点抑制剂在癌症治疗中表现有前途. 这项研究详细介绍了使用带有-89标记抗体的PET成像来可视化小鼠瘤模型中的免疫检查点表达.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
放射化学放射化学是指辐射化学.

背景情况:

免疫检查点抑制剂 (ICI) 是有效的癌症疗法,依赖于瘤微环境中的相互作用.
针对瘤或免疫细胞的编程死亡配体1 (PD-L1) 表达预测了ICI反应.
了解检查点动态对于优化免疫疗法至关重要.

研究的目的:

用PET成像描述评估免疫检查点表达的方法.
为了评估在体内可视化免疫检查点的-89标记抗体的使用.
在临床前癌症模型中研究免疫检查点表达的纵向动态.

主要方法:

使用正子发射断层扫描 (PET) 成像.
使用-89 (89Zr) 标记的抗体,针对免疫检查点.
在同基因小鼠瘤模型中应用该方法.

主要成果:

证明了使用89Zr标记抗体用于免疫检查点的PET成像的可行性.
想象了瘤和免疫细胞中免疫检查点的表达模式.
为纵向评估检查点动态提供了一个框架.

结论:

用89Zr标记抗体进行PET成像是研究免疫检查点表达的强大工具.
这种技术可以帮助预测和监测对免疫检查点抑制剂的反应.
允许在临床前模型中对瘤免疫微环境进行深入分析.

关键词:

抗体是对抗体的一种.癌症癌症癌症癌症免疫检查站免疫检查站在这里,PET是PET.-89 -89 -89 -89 -89 -89 -89 -89 -89 -89

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