用[18F]FSPG PET对瘤的抗氧化反应进行成像
Oskar Vilhelmsson Timmermand1, Timothy H Witney2
1School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Methods in molecular biology (Clifton, N.J.)
|November 25, 2023
概括
(4S) -4 -3-[18F]基) -L-胺酸 ([18F]FSPG) 是一种新型的PET成像剂. 它通过跟踪系统xc-活动来非侵入性地可视化细胞氧化还原状态和瘤抗氧化反应.
科学领域:
- 生物化学 生物化学
- 放射化学 放射化学是指辐射化学.
- 在瘤学瘤学.
背景情况:
- 细胞的氧化还原状态对于癌症的进展至关重要.
- 系统xc-,一个囊酸反载体,在许多癌症中被上调调节,并与谷氨生物合成有关.
- 谷氨是一种关键的抗氧化剂,使系统xc-活动成为细胞氧化还原反应的标记物.
研究的目的:
- 为了引入 (4S) -4-(3-[18F]利) -L-胺酸 ([18F]FSPG) 作为一种新的正子发射断层扫描 (PET) 成像剂.
- 为了证明[18F]FSPG对细胞氧化还原状态的非侵入性体内成像的实用性.
- 调查FSPG的潜力,用于成像与系统x-活动相关的瘤抗氧化反应.
主要方法:
- -18标记的谷氨酸类似物FSPG的合成和表征, [18F]FSPG.
- 使用PET成像来评估在临床前模型中FSPG的体内吸收和保留.
- 关联FSPG保留与系统x-表达和细胞氧化还原标记.
主要成果:
- [18F]FSPG通过系统xc-成功地穿过细胞膜.
- [18F]FSPG的组织保留反映了细胞内氧化还原状态和系统x活动.
- 使用[18F]FSPG进行PET成像,可实现瘤抗氧化反应的非侵入性可视化.
结论:
- [18F]FSPG是一种有前途的PET追踪器,用于评估细胞氧化还原状态和系统xc-活体活动.
- 这种成像方法可以非侵入性地评估瘤的抗氧化反应,可能有助于癌症诊断和治疗监测.
- [18F]FSPG PET成像的方法考虑得到了强调.
关键词:
(4S) -4 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -锡斯胺 (Cystine) 是一种氨酸.谷氨酸酸盐的使用方法葡萄糖氨酸 (Glutathione) 是一种在这里,PET是PET.这就是ROSOS ROS.[18F]FSPG 提供服务我们的XC是XC−.更多相关视频
10:47Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
Published on: February 3, 2015
8.8K
10:28Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
11.1K
相关概念视频
Positron Emission Tomography
4.2K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
4.2K
Imaging Studies II: Positron Emission Tomography and Scintigraphy
123
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Fundamental Principles of PET
123
Radiological Investigation III: Pulmonary Angiogram and PET Scan
95
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
95
