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在临床前的 pozitron 发射断层扫描成像中的动态建模方法

Agne Knyzeliene¹, Robert Shaw¹, Viktoria Balogh¹

¹Queen's Medical Research Institute, Edinburgh, UK.

Methods in molecular biology (Clifton, N.J.)

|November 25, 2023

概括

本章详细介绍了收集临床前正子发射断层扫描 (PET) 成像数据的逐步协议. 它可以在动物研究中进行详细的放射性追踪器分析的动态建模.

科学领域:

临床前成像学临床前成像学
核医学是一种核医学.
药理动力学药理动力学

背景情况:

pozitron发射断层扫描 (PET) 成像在临床前研究中越来越多的应用.
对PET数据的动态建模可以对放射性追踪器的行为产生多参数的洞察力.
了解放射性追踪剂的吸收和结合对于药物开发和疾病研究至关重要.

研究的目的:

为获取PET数据提供一个实用的,逐步的协议.
为了促进动物模型 (老鼠和小鼠) 的运动建模研究.
为可靠的动力分析标准化PET数据收集.

主要方法:

在老鼠和小鼠中获取PET数据的详细协议.
关于实验设置和成像参数的指导.
在随后的动力模型中强调数据质量.

主要成果:

一个用于临床前PET数据收集的综合性协议.
设计用于支持强大的动力模型的方法.
能够提取辐射追踪器动态上的定量参数.

结论:

提供的协议标准化了用于动力建模的PET数据收集.
促进在临床前模型中深入分析放射性追踪器动力学.
通过定量PET成像支持药物发现和理解生物过程的进步.

关键词:

自动抽取血液样本的自动化.自由分数的自由分数动态建模动态建模在PET成像中使用PET成像.临床前临床前量化量化量化量化放射性代谢物质是一种放射性代谢物质.

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