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相关概念视频

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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相关实验视频

Updated: Jul 10, 2025

How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index
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皮质形态和任务和休息状态的功能连接性之间的跨主体相似性与年龄相关的下降.

Junhong Yu1

  • 1Psychology, School of Social Sciences, Nanyang Technological University, 48 Nanyang Avenue, Singapore, 639798, Singapore. junhong.yu@ntu.edu.sg.

GeroScience
|November 25, 2023
PubMed
概括
此摘要是机器生成的。

老年人比以前认为的更加独特,显示出更大的大脑差异. 这项研究揭示了与年龄相关的大脑结构和功能的分歧,挑战了老化同质性的神话.

关键词:
衰老的衰老 衰老的衰老皮层厚度 皮层厚度功能连接性的功能连接性.跨学科的相似性.

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科学领域:

  • 神经科学是一个神经科学.
  • 老年学是一门学科.
  • 脑部成像 脑部成像

背景情况:

  • 认为老年人是一个同质的群体是一个常见的误解.
  • 以前的研究还没有充分探索与年龄相关的大脑结构和功能的差异.
  • 了解个体衰老的变化对于个性化医学和神经科学至关重要.

研究的目的:

  • 研究与年龄相关的大脑结构和功能的分歧.
  • 挑战老年人群中同质性的神话.
  • 为了检查皮质厚度和整个生命周期的功能连接性之间的关系.

主要方法:

  • 使用fMRI (2休息 + 5任务) 和皮质厚度 (CT) 数据分析功能连接 (FC).
  • 利用了两个寿命数据集,共有1161名参与者.
  • 在不同年龄组的CF和CT中,对象之间的相似性进行比较.

主要成果:

  • 平均而言,受试者之间的FC和CT相关性在老年人群中较弱.
  • 整个大脑的分析表明,与年龄相关的结构和功能的显著分歧.
  • 皮层厚度相似性预测了功能连接性相似性,突出了结构-功能合.

结论:

  • 研究结果表明,老年人与同龄人相比,与年轻人不同.
  • 这项研究揭穿了'所有老年人都是一样的'的神话,表明衰老的独特性更大.
  • 结果对神经指纹和理解整个生命周期的大脑行为关联有重大影响.