大脑衍生的神经营养因子在的可能作用
Raed AlRuwaili1, Hayder M Al-Kuraishy2, Ali I Al-Gareeb2
1Department of Internal Medicine, College of Medicine, Jouf University, Sakaka, Saudi Arabia.
Neurochemical research
|November 25, 2023
概括
大脑衍生神经营养因子 (BDNF) 在中起着复杂的作用,可能提供神经保护或促进病变发生. 需要进一步的研究来澄清其在性疾病中的双重作用.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
背景情况:
- 是一种神经系统疾病,由反复发作来定义.
- 脑衍生神经营养因子 (BDNF) 与发育和有关.
- 关于BDNF在中的作用有争议,它可能具有神经保护作用.
研究的目的:
- 审查BDNF在中的保护性和有害性作用.
- 探索BDNF和其他信号通路 (自,mTOR,PGN,α-Syn) 之间的关系.
- 了解这些通路如何调节BDNF/TrkB信号通路.
主要方法:
- 临床前和临床研究的文献综述.
- 分析BDNF与相关分子通路之间的相互作用.
- 综合目前关于BDNF在中的作用的证据.
主要成果:
- 在中,BDNF表现出保护性和有害性.
- BDNF信号传递受到自,mTOR,progranulin (PGN) 和α-Synuclein (α-Syn) 的影响.
- 在中BDNF的确切作用仍然存在争议.
结论:
- 中BDNF的作用是复杂和矛盾的.
- 评估BDNF水平需要考虑其他信号通路和类型.
- 进一步的临床前,分子和临床研究对于阐明BDNF在中的作用至关重要.
更多相关视频
11:44Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
Published on: January 19, 2022
2.5K
07:07Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury
Published on: February 10, 2020
10.6K
相关概念视频
Arteries of the Lower Limbs
192
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
192
The Blood-brain Barrier
47.4K
Overview
47.4K
Antiepileptic Drugs: Glutamate Antagonists
376
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
376
Brain Imaging
234
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
234
