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Updated: Jul 10, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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GPR101:建模与X结合性巨性相关的构成性活性受体

Stefano Costanzi1, Lea G Stahr1, Giampaolo Trivellin2

  • 1American University, Department of Chemistry, Washington, DC, USA.

Journal of molecular graphics & modelling
|November 25, 2023
PubMed
概括

遗传巨型症 (X-LAG) 与过度活跃的GPR101.1有关. 这项研究提供了对GPR101的结构性见解,揭示了其构成性活动,并为潜在的X-LAG治疗铺平了道路.

关键词:
阿尔法折叠是什么意思阿尔法折叠阿尔法折叠多元状态与G蛋白结合的受体 (GPCRs) 是一种在 GPR101 中,GPR101 包含了 GPR101.同性学建模的模拟.分子动力学分子动力学

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