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在皮下注射后,系统性类两类纳米纤维的输送

Mark H Barlek¹, David C Gillis¹, Simon A Egner²

¹Department of Surgery, University of Virginia, Charlottesville, VA, 22903, USA.

|November 25, 2023

概括

两的纳米纤维可以在皮下注射后被吸收到血液中. 负电荷和较低的内部秩序增强了这些药物输送系统的系统吸收.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
药物运输药物运输药物运输

背景情况:

两 (PA) 纳米纤维有效用于通过静脉注射 (IV) 进行向药物输送.
皮下注射为PA纳米纤维在医学中提供了更广泛的应用潜力.

研究的目的:

为了研究PA纳米纤维在皮下注射后的全身吸收.
为了确定纳米纤维凝聚力和电荷如何影响皮下注射后PA吸收.

主要方法:

使用溶液小角度X射线散射 (SAXS),圆形二元化和溶液广角X射线散射 (WAXS) 设计和表征了四种具有不同氨基酸序列的PA分子.
用光标记的PA与未标记的PA (95%:5%的摩尔比率) 联合组装,并以皮下方式给Sprague Dawley大鼠.
在注射后72小时内测量体内腹部光,以量化全身吸收.

主要成果:

负电荷和低内部秩序的PA纳米纤维在注射后1,6和24小时表现出最高的系统吸收率.
皮下注射PA纳米纤维导致白细胞数量的减少和24小时后葡萄糖水平的升高.
在注射后48小时,葡萄糖水平开始恢复正常.

结论:

两的纳米纤维可以在皮下注射后有效地被吸收到全身循环中.
纳米纤维的特性,特别是负电荷和低内部秩序,显著影响它们的系统吸收.
皮下输送PA纳米纤维为药物输送应用提供了可行的途径.

关键词:

吸收方式吸收方式药物输送是药物输送的过程.纳米纤维是一种纳米纤维.这是一种两类.皮下使用皮下使用皮下使用

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