感染SARS Cov-2是否会影响试管婴儿的结果 - 一个系统的审查和元分析
Harpreet Kaur1, Anil Chauhan2, Mariano Mascarenhas3
1Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, Bilaspur, Himachal Pradesh 174001, India.
European journal of obstetrics, gynecology, and reproductive biology
|November 25, 2023
概括
轻度或无症状的COVID-19 (冠状病毒疾病2019) 感染不会显著影响体外受精 (IVF) 的结果,包括怀孕率. 建议对更大的样本大小进行进一步的研究,以获得确的证据.
科学领域:
- 生殖医学和内分泌学.
- 传染病和病毒学 传染病和病毒学
- 公共卫生和流行病学
背景情况:
- COVID-19 (冠状病毒疾病2019) 与女性和男性生育能力和生殖功能的潜在影响有关.
- 现有研究提出了关于COVID-19对体外受精 (IVF) 结果的影响的相互矛盾的发现,包括卵巢储备,卵细胞和胚胎质量以及怀孕率.
研究的目的:
- 系统地审查和综合有关SARS-CoV-2感染对体外受精 (IVF) 结果影响的证据.
- 确定以前的COVID-19感染是否影响了关键的试管婴儿成功指标,例如临床怀孕率 (CPR),植入率和持续怀孕率 (OPR).
主要方法:
- 针对2020年1月1日至2022年10月15日期间发表的研究,在PubMed,EMBASE,SCOPUS,WHO COVID-19数据库,ClinicalTrials.gov和Cochrane Central进行了全面的电子数据库搜索.
- 包括观察性研究 (前性,后性,队列,病例对照),比较COVID-19受影响个体与未受影响对照中的IVF结果. 叙述性评论,案例研究和其他研究类型被排除在外.
- 使用纽卡斯尔-太华尺度 (NOS) 评估偏差风险,并使用GRADEpro.pro对证据质量进行分级.
主要成果:
- 在选了5046个记录后,最终审查包括了12项研究.
- 在临床怀孕率 (OR 0.90,95% CI 0.67-1.21),植入率 (RR 0.92,95% CI 0.68-1.23) 或正在进行的怀孕率 (RR 0.96,95% CI 0.79-1.15) 中,在COVID-19康复患者和对照组之间没有观察到统计学上显著的差异.
- 每位患者检测到的卵细胞的平均数量也没有显著差异 (平均差异为0.52,95% CI -1.45至2.49). 证据的确定性被评为低.
结论:
- 这次系统性审查发现,与对照组相比,以前的COVID-19感染对体外受精 (IVF) 周期的结果没有显著影响.
- 这些发现是基于观察性研究,通常采用小样本大小,证据的低确定性需要谨慎解释.
- 需要对更大的队列进行进一步的研究来证实这些结果,并提供有关SARS-CoV-2对生育治疗影响的更强有力的证据.
关键词:
艺术 艺术 艺术 艺术ART 结果 ART 结果辅助生殖技术 辅助生殖技术这就是Covid-19的原因.在COVID-19大流行中.在这个过程中,IVF IVF.试管婴儿结果 试管婴儿结果在体外受精 试管受精这就是SARS Cov-2病毒.更多相关视频
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