与疾病感知,焦虑和精神健康相关的临床因素在硬化性胆管炎:一个单一中心前性研究
Jeremy S Nayagam1, Wafaa Ahmed2, Matthew Farrant2
1Institute of Liver Studies, King's College Hospital, London, UK; Department of Inflammation Biology, King's College London, London, UK.
Clinics and research in hepatology and gastroenterology
|November 25, 2023
概括
患有原发性硬化性胆道炎 (PSC) 的患者会出现严重的焦虑,抑郁和焦虑. 这些心理健康挑战可能在PSC患者中更为普遍,这些患者的性酸酶水平较高,没有自身免疫特征,这表明需要进行例行查.
科学领域:
- 胃肠病学和肝病学 胃肠学和肝病学
- 精神病学和心理健康 精神病学和心理健康
- 临床研究 临床研究
背景情况:
- 初级硬化性胆道炎 (PSC) 与生活质量降低,抑郁和焦虑有关.
- 对于PSC中这些心理健康问题的特定风险因素,特别是那些具有自身免疫特征的风险因素,仍然不清楚.
- 了解这些因素对于将心理健康支持纳入临床护理至关重要.
研究的目的:
- 将心理健康评估纳入患有硬化性胆道炎 (SC) 患者的日常护理.
- 确定与SC患者的生活质量,疾病感知和心理健康相关的因素.
- 为了评估这种患者群体中担忧,抑郁和焦虑的患病率.
主要方法:
- 一项前性研究,涉及成年非移植性SC患者,持续一年.
- 电子自我报告问卷评估了临床访问前的担忧,疾病感知,抑郁和焦虑.
- 为了分析,收集了人口和临床数据.
主要成果:
- 40%的SC患者填写了问卷.
- 关注生活质量,心理,身体和未来健康的高度普遍性被观察到.
- 在没有自身免疫特征的PSC患者中,性酸酶升高与更高的焦虑和疾病感知相关. 抑郁症 (21.1%) 和焦虑症 (9.6%) 的查得分较高,独立于患者的因素.
结论:
- 电子问卷可以有效地纳入常规的SC临床护理.
- 在SC患者中存在明显的焦虑,抑郁和焦虑的流行.
- 建议对SC患者进行常规心理健康查,特别是那些酸酶升高且没有自身免疫特征的患者.
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