饮食补充中纳克尔减少了老年雌性小鼠的皮质骨损失
Dung Kim Nguyen1, Arnaud Vanden-Bossche1, Norbert Laroche1
1Université Jean Monnet Saint-Étienne, INSERM, Mines Saint Etienne, SAINBIOSE U1059, F-42023 Saint-Étienne, France.
Experimental gerontology
|November 25, 2023
概括
饮食中补充粉可以通过减少骨质细胞活性,改善老年雌性小鼠的皮层骨强度. 纳克还增加了脊椎骨的骨重塑,这表明有可能减少与年龄相关的骨质损失.
科学领域:
- 生物矿物化 生物矿物化
- 骨生物学 骨生物学 骨生物学
- 衰老研究研究 衰老研究
背景情况:
- 衰老会导致显著的骨损失,特别是皮层骨,导致脆弱性骨折.
- ,一种天然的软体动物产品,在之前的研究中已经显示出对骨的保护作用.
- 纳克对雌性小鼠老化相关的骨损失的影响,缺乏更年期,仍然未经评估.
研究的目的:
- 为了评估食对老化雌性小鼠骨质量和强度的影响.
- 为了比较纳克尔对标准和碳酸饮食的效果,超过90天.
- 研究对骨微型结构,机械特性和细胞活动的影响.
主要方法:
- 16个月大的C57BL/6雌性小鼠被食,CaCO3或标准饮食90天.
- 评估了骨微架构,机械性能和状组织形态测量.
- 分析了与骨细胞和骨循环标记物相关的基因表达.
主要成果:
- 通过减少骨质细胞活动标志物,食可以增强皮质骨强度.
- 拿克拉养的小鼠表现出增加的椎骨重塑与更高的骨质母细胞基因表达.
- 在这个年龄段,没有观察到椎微观架构的显著差异.
结论:
- 饮食中使用的黄在减轻与年龄相关的皮质骨损失方面表现有前途.
- 影响骨重塑过程,可能有利于老年人的骨健康.
- 进一步的研究可能会探索nacre在预防老年人骨折方面的有效性.
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