L.acidophilus通过影响Treg/Th17平衡,参与PM2.5诱导的肠炎
Jie Xu1, Jing Wang2, Yuefeng He1
1Yunnan Provincial Key Laboratory of Public Health and Biosafety & School of Public Health, Kunming Medical University, Kunming 650500, China.
Environmental pollution (Barking, Essex : 1987)
|November 25, 2023
概括
颗粒物 (PM2.5) 暴露会通过破坏Treg/Th17平衡和减少Lactobacillus acidophilus,导致肠道炎症. 补充L. acidophilus可以防止这种炎症.
科学领域:
- 环境健康 环境健康
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 颗粒物 (PM2.5) 与多器官损伤有关,对其胃肠道影响越来越感兴趣.
- 肠道是具有高微生物含量的主要免疫器官,易受PM2.5诱导的炎症.
研究的目的:
- 为了研究PM2.5引起的肠道炎症的机制.
- 探索肠道免疫系统和微生物群在PM2.5暴露中的作用.
主要方法:
- 在动物中建立了四种PM2.5暴露模型.
- 进行了调控性T细胞 (Treg) 移植实验.
- 使用16S rDNA第三代测序进行微生物分析.
- 对Lactobacillus acidophilus (L. acidophilus) 和Treg/Th17平衡进行了机制研究.
主要成果:
- 暴露于PM2.5诱导肠道炎症,通过在调节性T细胞 (Tregs) 和T辅助17细胞 (Th17) 之间产生不平衡.
- PM2.5显著降低了肠道中的L. acidophilus的丰度.
- 证实L. acidophilus参与了Treg/Th17的失衡.
- 补充L. acidophilus通过恢复Treg/Th17平衡缓解了PM2.5引起的肠炎症.
结论:
- 暴露于PM2.5会破坏肠道免疫平衡,特别是Treg/Th17平衡,导致炎症.
- L. acidophilus在缓解PM2.5引起的肠道炎症方面发挥着至关重要的作用.
- 补充L. acidophilus是一种潜在的治疗策略,可以预防PM2.5相关的肠损伤.
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