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在ccRCC中,circWSB1通过circWSB1/miR-182-5p/WSB1轴促进瘤进展
Guyu Tang1, Jing Liu2, Xiaomei Gao3
1Department of Urology, Disorders of Prostate Cancer Multidisciplinary Team, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, No.87 Xiangya Road, Changsha City 410008, Hunan Province, PR China.
International journal of biological macromolecules
|November 25, 2023
概括
像circWSB1这样的循环RNA (circRNAs) 在清细胞细胞癌 (ccRCC) 中高度表达. CircWSB1通过调节circWSB1/miR-182-5p/WSB1轴来促进ccRCC的进展,提供潜在的生物标志物和治疗点.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 清细胞细胞癌 (ccRCC) 呈现出低生存率的阴暗预后.
- 循环RNAs (circRNAs) 正在成为ccRCC中的关键调节者,但它们的具体作用需要阐明.
研究的目的:
- 研究ccRCC中circRNAs的表达模式和功能作用.
- 确定circRNAs作为潜在的诊断生物标记物和ccRCC的治疗点.
主要方法:
- 使用circRNA微阵列测序来分析ccRCC组织中的circRNA表达.
- 实验室和体内模型被用于探索已识别的circRNAs的功能机制.
- 研究了circWSB1,miR-182-5p和WSB1之间的相互作用.
主要成果:
- 在ccRCC组织中发现circRNA circWSB1的高度表达.
- 鉴定出CircWSB1与miR-182-5p相互作用,对其宿主基因WSB1.1进行上调.
- 环WSB1/miR-182-5p/WSB1轴促进了ccRCC细胞的增殖和迁移.
- 高表达的circWSB1和WSB1与较差的预后和先进的病理分级相关.
结论:
- 通过调节circWSB1/miR-182-5p/WSB1轴,CircWSB1在ccRCC中充当致癌性circRNA的作用.
- CircWSB1增强了ccRCC的进展,并与不良的临床结果有关.
- CircWSB1是一个有前途的预测生物标志物和ccRCC的治疗目标.
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