细胞内膜网膜应激,线粒体功能障碍及其交叉声在椎间盘退化中的作用
Dengbo Yao1, Enming Chen2, Yuxi Li2
1Department of Orthopedics Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.; Department of Orthopedics Surgery, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China.
Cellular signalling
|November 25, 2023
概括
椎间盘退化 (IVDD) 是腰部疼痛的一个原因,涉及细胞亡和细胞外基质退化. 细胞内膜网膜 (ER) 的压力和线粒体功能障碍,以及它们的交叉声,对IVDD的进展有显著的贡献.
科学领域:
- 细胞生物学 细胞生物学
- 生物化学 生物化学
- 生物医学工程 生物医学工程
背景情况:
- 腰部疼痛 (LBP) 是一个广泛的健康问题,椎间盘退化 (IVDD) 约占病例的40%.
- IVDD的发病包括细胞亡和细胞外基质 (ECM) 降解,受炎症,氧化应激和 (Ca2+) 恒温不平衡的影响.
研究的目的:
- 在IVDD中审查内质网膜 (ER) 应激和线粒体功能障碍的作用.
- 在IVDD的背景下,探索ER压力和线粒体之间的潜在交叉声.
- 为了确定IVDD干预的新型治疗策略.
主要方法:
- 文献综述侧重于IVDD的细胞和分子机制.
- 对研究ER压力和线粒体功能障碍在磁盘退化中的研究的分析.
- 对ER和线粒体在病理过程中的相互作用的研究进行了审查.
主要成果:
- ER压力启动细胞亡,并与炎症,氧化压力和Ca2+不平衡有关.
- 线粒体功能障碍,包括动力学和抗氧化系统,与活性氧物种 (ROS) 和炎症有关,促进细胞亡.
- ER和线粒体之间的交叉声通过信号通路,ROS和CHOP等分子发生,涉及线粒体相关膜 (MAM) 进行Ca2+传输.
结论:
- ER压力和线粒体功能障碍是IVDD的关键因素.
- 在IVDD病原发生过程中,ER和线粒体之间的交叉交互起着至关重要的作用.
- 向ER-线粒体通信为IVDD提供了一个有希望的治疗途径.
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