在出生时体重非常低的婴儿中,体重增长速度和生长结果发展为主要疾病
Ting-Hsuan Sung1, Chi-Shuo Lin2, Mei-Jy Jeng3
1Division of Neonatology, Department of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Department of Pediatrics, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.
Pediatrics and neonatology
|November 25, 2023
概括
非常低出生体重婴儿的子宫外生长限制 (EUGR) 与妊娠年龄和出生体重有关. 尽管早期生长速度较慢,但诸如支气管肺功能障碍等特定疾病并没有直接导致EUGR.
科学领域:
- 新生儿科学 新生儿科学
- 儿科生长与发展 儿科生长与发展
- 围产儿医学 围产儿医学
背景情况:
- 宫外生长限制 (EUGR) 在出生时体重非常低 (VLBW) 的婴儿中很普遍,可能会影响神经发育.
- 虽然早产婴儿的生长速度有所增加,但其与EUGR和发病率的关系尚不清楚.
研究的目的:
- 调查生长速度,子宫外生长限制 (EUGR) 和早产儿患病率之间的关系.
- 分析与VLBW婴儿的EUGR相关的因素.
主要方法:
- 对263名2012-2020年间出生婴儿 (出生体重<1500克,妊娠年龄24-33周) 的回顾性分析.
- 使用指数模型计算平均生长速度,并分析体重Z分数.
- 多变量建模以确定与EUGR相关的因素在36周的修正妊娠年龄或出院时.
主要成果:
- 平均生长速度为11.8 ± 0.3 g/kg/天,在产后4周达到顶峰 (16.4 ± 0.9 g/kg/天).
- 较低的出生体重,更高的妊娠年龄,肠道手术和延迟的全肠养与评估时较低的体重百分比有关.
- 大多数常见的早产并发症并没有显著影响体重Z-score或Z-score变化.
结论:
- 在VLBW婴儿中,EUGR主要与妊娠年龄和出生体重有关.
- 虽然诸如支气管肺张力症,腹腔内出血和早产视网膜病变等疾病与早期生长缓慢相关,但它们并没有直接导致EUGR.
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