通过离散选择实验识别的高级神经内分泌瘤治疗决策的患者优先事项
Matthew Anaka1,2, David Chan3, Sharon Pattison4
1Cross Cancer Institute, Alberta Health Services, Edmonton, Alberta, Canada.
The oncologist
|November 25, 2023
概括
神经内分泌瘤 (NET) 患者对治疗的偏好有所不同. 虽然许多人优先考虑更长的无进展生存期 (PFS),但很大一部分人认为不良事件 (AE) 率较低或侵入性较小的选择,这强调了共享决策的重要性.
科学领域:
- 在瘤学瘤学.
- 医学经济学 医学经济学
- 患者报告的结果
背景情况:
- 先进的神经内分泌瘤 (NETs) 提供了多种不同的治疗选择.
- 医生和患者在治疗属性 (如不良事件 (AE) 率) 方面的优先事项之间存在差异.
- 了解患者偏好对于在NET管理中以患者为中心的决策至关重要.
研究的目的:
- 为了引起中肠和胰腺NET (pNET) 晚期患者的治疗偏好.
- 确定治疗属性的相对效用排名,包括无进展生存 (PFS),治疗方式和AE率.
- 为特定的NET治疗概况确定患者优先级.
主要方法:
- 采用了两个离散选择实验 (DCE),采用了所有可能的替代品 (PAPRIKA) 方法的潜在所有对对排名.
- 从110名中肠NET和132名pNET患者中引起了偏好.
- 属性水平是从NET治疗的随机临床试验数据中得出的.
主要成果:
- 较长的PFS是大多数参与者的首要偏好 (64.5%的中肠,59%的pNET).
- 大约40%的参与者优先考虑较低的AE率或比PFS更少的侵入性模式.
- 在中肠NET中,60.9%的人赞成受体放射性核酸治疗 (PRRT),30.0%的人赞成Somatostatin模拟剂量升级.
结论:
- 神经内分泌瘤患者表现出异质的治疗优先级.
- 患者的偏好在无进展生存期,不良事件和治疗侵入性方面各不相同.
- 共享决策对于优化NET患者的治疗选择至关重要.
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