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全身PET-CT中瘤异质性的空间映射:一个可行性研究

Hanna Jönsson¹, Håkan Ahlström^2,3, Joel Kullberg^2,3

¹Section of Radiology, Department of Surgical Sciences, Uppsala University, 751 85, Uppsala, Sweden. hanna.jonsson@surgsci.uu.se.

Biomedical engineering online

|November 25, 2023

概括

使用全身PET-CT图像量化空间瘤异质性是可行的. 这种方法揭示了不同癌症类型的病变分布和代谢活动的变化,有助于改善癌症管理.

科学领域:

医疗成像医学成像
在瘤学瘤学.
无线电学 (Radiomics) 是一种无线电学.

背景情况:

瘤异质性会影响治疗反应和患者的治疗结果.
量化跨尺度的异质性为癌症管理提供了关键的见解.

研究的目的:

评估基于图像注册的框架,用于研究全身PET-CT图像中的空间瘤异质性.
分析肺癌,淋巴瘤和黑色素瘤患者队列中的异质性.

主要方法:

使用了490个FDG-PET-CT扫描的数据集.
采用图像注册框架来提取voxel,损伤和主体级特征.
将特征映射到模板空间,以进行分位元分析,并使用Pearson的相关性比较空间属性.

主要成果:

在癌症子集中,在病变分布,代谢活动和体积方面表现出空间异质性.
损伤特征地图突出显示了解剖变异和高间损伤变异性的部位.
主题空间中的空间特性与模板空间测量有很强的相关性 (例如,损伤体积R=0.986).

结论:

拟议的框架成功地在全身PET-CT图像中探索了空间瘤异质性.
全身研究容易受到损伤频率的区域差异的影响,这会影响统计能力.

关键词:

瘤的分布瘤的分布瘤异质性瘤异质性沃克塞尔智能分析分析整个身体的PETCT.

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Positron Emission Tomography

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
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