DNA-ICM作为一种辅助方法,应用于口腔细胞学样本
Mariana Goveia Melo Ribeiro1, Silvio Santana Dolabella2, Cleverson Luciano Trento3
1Federal University of Santa Catarina, Department of Clinical Analysis, Florianópolis, Santa Catarina, Brazil.
Oral surgery, oral medicine, oral pathology and oral radiology
|November 26, 2023
概括
将细胞学与DNA图像细胞计结合起来,可以提高口腔癌诊断的准确性. 这种非侵入性方法显示出高灵敏度和特异性,用于检测在口腔中的恶性表皮状状细胞转化.
科学领域:
- 口腔病理学 口腔病理学
- 细胞病理学 细胞病理学
- 在瘤学瘤学.
背景情况:
- 口腔癌的诊断依赖于准确的早期检测方法.
- 潜在的恶性和恶性口腔病变需要精确的诊断工具.
- 细胞学是一种常见的诊断技术,但它的准确性可以得到改善.
研究的目的:
- 评估细胞学在结合口腔癌辅助方法时的诊断准确性.
- 评估DNA图像细胞计作为口腔细胞学辅助技术的有效性.
- 在常规临床实践中确定组合方法的灵敏度和特异性.
主要方法:
- 一项前性研究,涉及98名患有口腔病变的患者.
- 在活检前使用细胞刷采集细胞学涂片.
- 在相同的细胞学幻灯片上进行的DNA ploidy测量.
- 对诊断准确度,灵敏度和特异性的分析.
主要成果:
- 细胞学与DNA图像细胞计结合显示了81.2%的灵敏度和90.9%的特异性.
- 对于高风险的口腔恶性瘤部位,联合方法实现了88.2%的灵敏度和100.0%的特异性.
- 对于高风险病变,观察到准确率为90.0%和卡帕值为0.77.
结论:
- 细胞学与DNA图像细胞计的结合是一种客观的,非侵入性的诊断方法.
- 这种结合方法在诊断口腔上皮质状细胞转化方面表现出高灵敏度和特异性.
- 这些发现支持在常规口腔癌诊断中使用这种辅助技术.
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