多基因风险得分与整个寿命的血压特征有关
Karsten Øvretveit1, Emma M L Ingeström2, Michail Spitieris1,3
1K.G. Jebsen Centre for Genetic Epidemiology, Faculty of Medicine and Health Sciences, Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Postboks 8905, N-7491 Trondheim, Norway.
European journal of preventive cardiology
|November 26, 2023
概括
血压特征的多基因风险评分 (PRS) 在儿童时期出现,并持续到成年. 这些遗传倾向会影响整个生命周期内心血管和脏疾病的风险,突出早期识别潜力.
科学领域:
- 遗传学 遗传学 是一个
- 心血管疾病 心血管疾病
- 公共卫生 公共卫生
背景情况:
- 全球有超过10亿人患有高血压,是致病率和死亡率的重要原因.
- 血压 (BP) 的特征是遗传的,多基因风险得分 (PRS) 量化遗传贡献.
- 关于BP PRS在儿童群体中的表现的研究有限.
研究的目的:
- 为了评估血压多基因风险得分 (PRS) 在儿童时期的表现.
- 通过使用BP PRS. 调查基因型-表型关联和整个寿命的疾病风险.
- 为了确定生命早期对高血压的遗传风险是否延续到成年.
主要方法:
- 使用各种权重方法,开发了多重PRS用于心血压,腹血压和脉冲压.
- 在独立的儿科和成人队伍中应用高性能PRS.
- 基因型-表型关联和疾病风险分层的分析基于PRS的分辨率.
主要成果:
- 低,平均和高PRS组之间的BP轨迹的差异从幼儿时期就显而易见,并持续到成年.
- 高PRS个体显示心血管和脏疾病风险增加,而低PRS个体显示风险降低.
- 血压特征的遗传风险因素从生命的最早几年开始就与血压特征有关.
结论:
- 对高血压的遗传倾向可以在儿童早期被检测出来,并在整个生命中保持下来.
- 在疾病发作之前,PRS可以识别高遗传高血压风险的个体.
- 利用PRS进行早期诊断可能有助于进行原始预防,并减少高血压对公众健康的负担.
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