强化塞法托林剂量的关键成分对药理动力学/药理动力学目标实现的影响
Iris K Minichmayr1, Sebastian G Wicha2, Peter Matzneller3,4
1Department of Clinical Pharmacology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria. iris.minichmayr@meduniwien.ac.at.
Clinical pharmacokinetics
|November 26, 2023
概括
对于敏感细菌来说,缩短塞法托林剂量间隔是实现目标的关键. 对于不太敏感的细菌,增加每日总剂量是最有效的.
科学领域:
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
- 临床药房 临床药房
背景情况:
- 塞法托林 (Ceftaroline fosamil) 是一种β-lactam抗生素,用于复杂的皮肤和软组织感染.
- 批准的剂量包括每天两次或三次600毫克.
- 有效性取决于药理动力学/药理动力学 (PK/PD) 目标,特别是针对金黄色葡萄球菌.
研究的目的:
- 系统地评估剂量方案组件对塞法托林PK/PD目标实现的影响.
- 评估细菌敏感性对强化剂量策略有效性的影响.
- 为了优化对各种黄金葡萄球菌MICs的Ceftaroline剂量.
主要方法:
- 在健康志愿者中开发了一种种群体药理动力学 (PK) 模型.
- 在不同剂量间隔,输液持续时间和总每日剂量 (TDD) 下,比较了PK/PD目标实现 (ƒT>MIC).
- 在一系列黄金葡萄球菌最低抑制度 (MICs) 的评估场景.
主要成果:
- 一个两部分的PK模型描述了ceftaroline的度.
- 对于敏感病原体 (MIC ≤1 mg/L),缩短剂量间隔 (q8h) 是实现目标的主要驱动因素.
- 对于不太敏感的病原体,增加的TDD显示了最大的改善 ƒT>MIC.
结论:
- 优化剂量方案为ceftaroline取决于细菌的敏感性.
- 缩短剂量间隔对于敏感菌株至关重要.
- 增加每日总剂量对不太敏感的菌株最有效,特别是在延长输液持续时间时.
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