基于网络药理学和分子对接的 Baihe Zhimu 的抗抑郁机制的探索
1Jinan University Zhuhai Campus, Zhuhai, Guangdong, 519000, China.
Studies in health technology and informatics
|November 26, 2023
概括
白河 (Baihe Zhimu decoction,简称BZD) 通过多种活性成分和点来治疗抑郁症,包括kaempferol和Stigmasterol,影响PI3K-Akt信号传递等关键通路. 这项研究提供了关于BZD抗抑郁机制的见解.
科学领域:
- 药理学 药理学是指药理学的学科.
- 网络药理学网络药理学
- 传统中国医药 传统中国医药
背景情况:
- 抑郁症是一种复杂的精神障碍,治疗选择有限.
- 传统中医 (TCM) 提供了潜在的治疗策略.
- 白河 (Baihe Zhimu decoction,简称BZD) 是一种具有潜在抗抑郁作用的经典药物.
研究的目的:
- 通过网络药理学阐明 Baihe Zhimu (BZD) 的抗抑郁机制.
- 确定关键的活性成分,点和参与BZD抗抑郁作用的途径.
- 为BZD的临床应用和药物开发提供科学基础.
主要方法:
- 利用TCMSP数据库识别Baihe和Zhimu的活跃组件和目标,根据ADME标准进行过.
- 从Gencards,OMIM和DRUGBANK数据库中提取了主要的抗抑郁目标.
- 使用String平台和分析的功能模块构建了蛋白质与蛋白质相互作用 (PPI) 网络.
- 使用Metascape平台进行路径和生物过程丰富分析.
- 在Systems Dock网站上通过分子对接验证了分子相互作用.
主要成果:
- 确定了凯姆菲罗尔和斯蒂格马斯特罗尔作为BZD治疗抑郁症的核心活性成分.
- 确定的核心目标包括AKT1,TNF,TP53,PTGS2和CASP3.
- 发现抗抑郁途径主要涉及脂质和动脉样硬化,化学致癌和受体激活.
- 分子对接证实了kaempferol/Stigmasterol与目标AKT1,TNF和TP53.3之间的良好亲和力.
结论:
- BZD的抗抑郁机制涉及多个组成部分,目标和途径.
- 潜在的机制包括神经活性联体受体相互作用,动脉样硬化调节,PI3K-Akt信号传递和TNF信号通路.
- 这项研究为BZD对抑郁症的治疗效果提供了基础的理解.
相关概念视频
Antidepressant Drugs: MAOIs and Other Agents
248
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
248
Antidepressant Drugs: Overview
511
Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
511
G-protein Coupled Receptors
119.6K
G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
119.6K
Depression: Overview
252
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
252


