在恐慌障碍中休息状态皮质 - 边缘功能连接模式:与情绪调节策略使用和症状严重程度的关系
Hai-Yang Wang1, Lin Zhang2, Bei-Yan Guan3
1Department of Neurology, Jining No. 1 People's Hospital, Shandong First Medical University, Jining, 272000, China.
Journal of psychiatric research
|November 26, 2023
概括
患有恐慌障碍 (PD) 的患者在前额叶皮层 (PFC) 和杏仁体之间的静止状态功能连接 (rsFC) 减少. 这种受损的PFC-杏仁体rsFC与PD严重程度有关,并调解认知重新评估的情绪调节策略.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 功能神经成像 功能神经成像
背景情况:
- 认知重新评估是关键的情绪调节策略.
- 前额叶皮层 (PFC) 活动在重新评估期间调节杏仁体功能.
- 异常的PFC-杏仁体电路与恐慌障碍 (PD) 有关.
研究的目的:
- 调查PD中PFC和杏仁体之间的静止状态功能连接 (rsFC).
- 检查PFC-杏仁体rsFC与认知重新评估的关联.
- 探索PFC-桃体rsFC在认知重新评估和PD严重程度之间的关系中的调解作用.
主要方法:
- 休息状态功能磁共振成像 (rsfMRI) 在26名未经治疗的PD患者和25名健康对照 (HC) 中.
- 评估认知重新评估习惯和PD症状严重程度.
- 调解分析,以评估PFC-杏仁体rsFC的作用.
主要成果:
- 与HC相比,PD患者在PFC和杏仁体之间显著减少了rsFC.
- 较低的PFC-杏仁体rsFC与更大的PD症状严重程度相关.
- 认知重新评估与PD严重程度有负面关联,PFC-杏仁体rsFC调解了这种关系.
结论:
- 异常的PFC-杏仁体rsFC是恐慌障碍的一个关键特征.
- 这种改变的连接性可能会调解PD认知重新评估的有效性.
- PFC-桃体rsFC可以作为PD监测和治疗的生物标志物.
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