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有效的SARS-CoV-2感染对抗通过 rhACE2 ectodomain 在Avidin-Nucleic-Acid-NanoASsimilar上多元化

Simone Bernardotto¹, Ilaria Frasson², Silvia Faravelli³

¹Pharmaceutical and Pharmacological Sciences Dept (DSF), University of Padova, Via Marzolo, 5. 35131, Padova, Italy.

|November 26, 2023

概括

在纳米颗粒上使用ACE2受体的新型纳米诱有效抑制SARS-CoV-2感染,包括Omicron变种. 这种自组装系统对广泛的抗病毒应用和安全的鼻腔输送充满希望.

科学领域:

生物技术是生物技术.
纳米医学是一种纳米医学.
病毒学病毒学

背景情况:

传统的抗病毒策略需要补充工具.
基于脂质的纳米纤维用于受体定,存在制造方面的挑战.
需要替代的纳米结构来实现病毒受体的多元化.

研究的目的:

为SARS-CoV-2开发一种半合成自组装纳米诱.
评估纳米颗粒上的多重化ACE2受体对SARS-CoV-2的疗效.
评估纳米诱在治疗应用中的潜力.

主要方法:

通过将ACE2ectodomain多元化到聚-阿维丁纳米粒子 (ANANAS) 上,构建了一个纳米诱.
在各种ACE2:纳米粒子比率下测量了人类肺细胞中的SARS-CoV-2感染抑制.
评估了ACE2:病毒受体结合域 (RBD) 亲和力.
通过鼻腔灌注在小鼠中评估纳米诱生物分布和安全性.

主要成果:

在纳米ACE2度下达到90%的SARS-CoV-2抑制,具有最佳ACE2密度 (30:1比率).
与单体ACE2相比,对武汉和Omicron变种的有效性是十倍的.
确定了纳米粒子-病毒相互作用的最佳几何关系.
在活体中显示出有前途的生物分布和安全概况,用于鼻腔输送.

结论:

基于的纳米诱为抗病毒疗法提供了一个强大而适应性的平台.
优化受体密度对于有效的纳米诱病毒识别至关重要.
该纳米诱系统适用于鼻腔灌注,并可能适用于其他病毒感染.

关键词:

艾维丁 - 生物阿维丁-核酸-纳米AS看起来很像.功能性的纳米粒子.这就是SARS-CoV-2病毒.病毒诱是一种病毒诱.病毒预防病毒预防

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