阻塞性睡眠呼吸暂停和儿童的定期四肢运动:真的存在关联吗?
C González-Merino1, E Martínez-Cayuelas2, A Ladrón-Guevara2
1Autonomous University of Madrid, Health Research Institute-Fundación Jiménez Díaz University Hospital, Universidad Autónoma de Madrid (IIS-FJD, UAM), 28040, Madrid, Spain.
Sleep medicine
|November 26, 2023
概括
阻塞性睡眠呼吸暂停 (OSA) 和定期四肢运动 (PLM) 之间的关联可能被高估了. 更新的评分标准显示,在患有OSA和没有OSA的儿童之间,PLM没有显著差异,这挑战了以前的发现.
科学领域:
- 睡眠医学 睡眠医学
- 儿科肺病学 儿科肺病学
- 神经学 神经学
背景情况:
- 定期四肢运动 (PLM) 是与睡眠相关的运动,可以独立发生或与其他睡眠障碍一起发生,如阻塞性睡眠呼吸暂停 (OSA).
- 以前的研究表明OSA和PLM之间存在联系,但这些研究是基于较旧的诊断标准.
- 最近对世界睡眠医学协会 (WASM) 对呼吸相关腿部运动 (RRLM) 标准的修改可能会影响OSA和PLM之间的相关性.
研究的目的:
- 通过更新的评分标准,研究儿童的阻塞性睡眠呼吸暂停 (OSA) 和定期四肢运动 (PLM) 之间的关联.
- 确定与呼吸相关的腿部运动 (RRLM) 的修订定义是否会影响OSA和PLM之间的关系.
主要方法:
- 一项涉及131名疑似睡眠呼吸障碍儿童 (5-12岁) 的研究进行了.
- 分析了多睡眠学 (PSG) 数据,65名儿童被诊断患有OSA,66名患有打但没有OSA.
- 用2006年和2016年WASM/IRLSSG标准手动评分腿部运动.
主要成果:
- 使用2006年WASM规则,在OSA和非OSA组之间发现了PLM指数的显著差异.
- 然而,在应用2016年WASM规则时,没有观察到PLM指数,非REMPLM指数,REMPLM指数或具有唤起指数的PLM的统计差异.
- 患有PLM>5/h的儿童百分比从采用旧标准的38.93%下降到采用更新标准的19.08%.
结论:
- 更新的WASM/IRLSSG评分规则表明,OSA和PLM之间的关联可能被高估了.
- 根据新的标准,缺乏明确的关联,加上不清楚的病理生理学,表明这种关系可能并不像以前认为的那样重要.
- 需要进一步的研究才能充分理解OSA和PLM之间的复杂相互作用.
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