新辅助化疗后为HPV相关的桃体癌进行手术:成像是否反映了病理反应?
Geun-Jeon Kim1, Jooin Bang1, Hyun-Il Shin1
1Department of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
概括
术后的新辅助化疗对人类乳头瘤病毒 (HPV) 相关的桃体癌有效. 化疗后较大的瘤体积减少预测了完整的病理反应,可能减少了辅助治疗的需要.
科学领域:
- 在瘤学瘤学.
- 头部和部癌症 头部和部癌症
- 临床研究 临床研究
背景情况:
- 人类乳头瘤病毒 (HPV) 相关的桃体癌需要有效的治疗策略.
- 术后的新辅助化疗是管理这种疾病的新兴方法.
研究的目的:
- 评估使用新辅助化疗和随后的手术治疗桃体癌的结果.
- 评估瘤体积减少和病理反应之间的相关性.
主要方法:
- 38名患有HPV相关的桃体癌的患者接受了新辅助化疗,随后进行了手术.
- 在化疗后测量了瘤体积的减少,并与组织病理学发现相关联.
主要成果:
- 完整的病理反应 (pCR) 率在主要部位为60%,在节点部位为45%.
- 瘤体积减少≥78.8%,预测宫节点pCR.
- 新辅助化疗减少了不良的病理特征,减少了辅助治疗的需要.
结论:
- 术后的新辅助化疗是HPV相关桃体癌的可行的治疗方法.
- 化疗后显著的瘤体积减少是完全病理反应的预测指标.
更多相关视频
相关概念视频
01:26Tonsillitis II: Management
114
This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
114
01:23Chronic Pharyngitis
2.4K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
2.4K