糖尿病患者和非糖尿病患者的足部皮肤的机械特性
Sarah R Crossland1, Francesca Sairally1, Jen Edwards2
1Department of Mechanical Engineering, University of Leeds, Leeds, UK.
Journal of the mechanical behavior of biomedical materials
|November 26, 2023
概括
糖尿病人的足部皮肤比非糖尿病人的皮肤更硬,这会影响的风险. 了解这些机械差异是改善整形干预和糖尿病护理患者结果的关键.
科学领域:
- 生物力学 生物力学
- 生物材料科学 生物材料科学
- 皮肤病学 皮肤病学
背景情况:
- 糖尿病足带来重大健康风险,包括截肢和死亡率高.
- 目前对糖尿病足道的了解有限,这阻碍了有效的整形干预.
- 现有的研究经常将皮肤和皮下组织结合起来,使脚部皮肤机制的分析变得复杂.
研究的目的:
- 研究糖尿病和非糖尿病个体的足部皮肤的机械性质.
- 描述脚部皮肤内在的前应力和拉伸/压缩特性.
- 为改善糖尿病足的物理和计算模型提供数据.
主要方法:
- 数字图像相关性被用来测量脚部皮肤前紧张.
- 在切除的足部皮肤样本上进行了拉伸应力-应变分析和动态机械分析 (DMA).
- 在物理频率的拉伸和压缩负荷下评估了机械性能 (斯模量,储存和损失模量).
主要成果:
- 糖尿病供体的足部皮肤样本与非糖尿病供体相比,呈现出更高的中位Young模量和拉伸储存/损失模量.
- 平均模是0.83 ± 0.49 MPa的非糖尿病人和1.33 ± 0.43 MPa的糖尿病人标本.
- 压缩负荷显示了糖尿病和非糖尿病队列之间一致的中位储存和损失模块.
结论:
- 糖尿病患者和非糖尿病患者之间,脚部皮肤的机械特性不同,即使没有皮下组织.
- 糖尿病人足部皮肤的硬度增加可能会在日常负荷条件下导致的风险.
- 这些发现提高了对脚部组织生物力学的理解,以改善治疗策略.
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